Current Issue

VOL 12 NO 5 • JULY 2021

This issue’s cover illustration depicts the phagocytosis of autoantibody-covered platelets by an activated splenic macrophage. Thrombopoietin receptor agonists (TPO-ARs) are indicated by the glowing red balls, which are being used in conjunction with fostamatinib, an oral spleen tyrosine kinase (SYK) inhibitor, indicated by the yellow dots. There are no clear clinical guidelines for sequence therapy involving these two medications and switching from TPO-ARs to fostamatinib; patient-specific factors should be taken into consideration. Artwork by Alexandra Webber Baker © 2021, DNA Illustrations, Inc., Asheville, North Carolina.


Publish or Perish

Beth Faiman, PhD, MSN, APRN-BC, AOCN®, FAAN

As a newly hired nurse practitioner with barely a week of experience in the position, I was approached by a physician colleague at the end of a busy morning clinic. Excitedly, he said, “We are so happy to have you work with us. Can you see the patients in our afternoon clinic? I have a paper due ...

Research and Scholarship

Understanding Attitudes and Roles of Oncology Advanced Practitioners in the Setting of Cancer Clinical Trials: A Pilot Study

Christa Braun-Inglis,(1,2) MS, APRN-Rx, FNP-BC, AOCNP®, Yurii B. Shvetsov,(2) PhD, Ashley Springer,(3) MSN, APRN-Rx, AGPCNP-BC, Valerie Ferguson,(4) MSN, APRN-Rx, FNP-C, AOCNP®, Tyler Workman,(5) MS, APRN-Rx, AGPCNS-BC, Dee Ann Omatsu,(6) MS, APRN-Rx, PNP-BC, CPON, Francisco Conde,(7) PhD, APRN-Rx, AOCNP®, FAAN, Erin O’Carroll Bantum,(2) PhD, and Jessica Rhee,(2) MD

Nurse practitioners, physician assistants, and pharmacists, known collectively as advanced practitioners (APs), are highly trained and skilled health-care providers who contribute significantly to quality cancer care. They have been identified multiple times as part of the solution to the project...

Research and Scholarship

Early Palliative Care for Oncology Patients: How APRNs Can Take the Lead

Heidi Mason,(1,2) DNP, ACNP-BC, Mary Beth DeRubeis,(2) MSN, FNP-BC, and Beth Hesseltine,(2) MSN, FNP-C

Patients need expert care throughout their disease trajectory (Kain & Eisenhauer, 2016). It is important to maximize the quality of life (QOL) of patients throughout the course of their disease in order to prevent expensive and often futile treatment that can ultimately cause increased suffer...

Review Article

Treatment Options for Germline BRCA-Mutated Metastatic Pancreatic Adenocarcinoma

Doreen Grzelak, NP-C, AOCN®, AGN-BC

Pancreatic cancer currently accounts for 3.2% of all cancers. It is the fourth leading cause of death from cancer in both men and women. In 2020, it was estimated to affect more than 57,600 adults and lead to approximately 48,000 deaths (American Cancer Society, 2020). Approximately 10% of pancre...

Review Article

Nipple-Sparing Mastectomy in Breast Cancer: Impact on Surgical Resection, Oncologic Safety, and Psychological Well-Being

Lisa Parks, MS, APRN-CNP, ANP-BC

The first mastectomy with preservation of skin and nipple-areola complex (NAC) was performed for benign disease in 1951 (Orzalesi et al., 2016). Early experience with immediate breast reconstruction came from women having mastectomies for benign disease. Nipple-sparing mastectomy (NSM) has been u...

Grand Rounds

Transitioning From Thrombopoietin Agonists to the Novel SYK Inhibitor Fostamatinib: A Multicenter, Real-World Case Series

David M. Hughes,(1) PharmD, BCOP, Charina Toste,(2) DNP, APN, Christopher Nelson,(3) ACNP-BC, Juliet Escalon,(4) ANP, Frances Blevins,(5) PA-C, and Bhavesh Shah,(1) RPh, BCOP

Case Studies Case Study 1 A 25-year-old Hispanic female was diagnosed with chronic immune thrombocytopenia (ITP) at the age of 16 in Guatemala (2012) presenting with symptoms of gingival bleeding, petechiae, and easy bruising. Her platelet count was 9,000/∝L without causality. She was initiated a...

Grand Rounds

Management of Adverse Events Associated With Tyrosine Kinase Inhibitor Use in Adult Patients With Chronic Myeloid Leukemia in Chronic Phase: An Advanced Practice Perspective

Stephanie Bauer, RN, MSN, BC-FNP, Holly Comer, MSN, APRN, Brooke Ramsey, RN, MSN, ANP-BC, and Katy Thomas, RN, MSN, ANP-C

Case Studies Case Study 1: Pleural Effusion An 82-year-old man was diagnosed with chronic-phase CML with baseline BCR-ABL1 levels of 0.56% by FISH and cytogenetics revealing t(9;22). His medical history included coronary artery disease, atrial fibrillation, hypertension, and hypothyroidism. The p...

Practice Matters

Ensuring the Safety of Hospitalized Oncology Patients During a Pandemic

Meghan Mastrangelo, MSN, AGACNP-BC, Sara Muir, MSHS, PA-C, and Erin Marturano, MBE, MSN, RN

The societal impacts of the COVID-19 pandemic have been devastating and far reaching, and the effects on the health-care industry have been unparalleled. The pandemic forced health-care systems to reinvent and restructure at a dizzying pace, with no precedent from which to learn. Hospitals in the...

Prescriber's Corner

Pegfilgrastim Biosimilars: Where Are We Now?

Christopher Selby,(1) PharmD, BCOP, Breanne Peyton-Thomas,(2) PharmD, BCOP, and Parnian Eslami,(3) PharmD

Chemotherapy-induced neutropenia is one of the major dose-limiting toxicities of many cancer treatments. Neutropenia is defined as an absolute neutrophil count (ANC) of < 500 cells/mm3 or an expected decrease to < 500 cells/mm3 during the next 48 hours. This, combined with a single oral tem...

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