Current Issue

VOL 12 NO 7 • SEP/OCT 2021

This issue’s cover illustration depicts vulvovaginal graft-vs.-host disease, or VVGvHD. Shown in the image is an affected genital tract overlay on a normal state. The labia minora and majora have experienced a loss of architecture, and there are skin fissures present along with vaginal stenosis and adhesions. Overlaying graphic shows cellular components of the disease including donor T cells, host APC, the JAK-stat pathway of the T cell, MHCII, and other immune cells. Artwork by Alexandra Webber Baker © 2021, DNA Illustrations, Inc., Asheville, North Carolina.


Advanced Practitioners as Allies and Advocates

Beth Faiman, PhD, MSN, APRN-BC, AOCN®, FAAN

Advanced practitioners (APs) are a growing proportion of the health-care team. As of 2019, there were approximately 325,000 nurse practitioners, 7,000 clinical nurse specialists, and nearly 140,000 physician assistants in the United States (American Academy of Nurse Practitioners, 2021; National ...


On Becoming an Ally

Josh Epworth, ARNP

Earlier this year, I was asked to participate in a meeting titled “Virtual Summit to Define the Role of Oncology Advanced Practitioners in Equitable Cancer Care Delivery: A Closer Look at Care Coordination, Clinical Trials, and Implicit Bias” held by the Association of Community Cancer Centers (A...

Research and Scholarship

Current Testing Guidelines: A Retrospective Analysis of a Community-Based Hereditary Cancer Program

Margaret Ward,(1) DNP, APRN, AGN-BC, Betty Elder,(2) PhD, RN, and Maryon Habtemariam,(2) DNP, APRN

Approximately 5% to 10% of all cancers can be related to germline pathogenic variants (Marta et al., 2019), although that number is expected to climb as more information on the genetic origin of cancers becomes available. At this time, up to 24% of ovarian cancers (Ring et al., 2017), 10% of panc...

Research and Scholarship

Short- and Long-Term Outcomes of Hematologic Malignancy Patients After Cardiopulmonary Resuscitation: Experience of a Large Oncology Center

Mary Lou Warren, DNP, APRN, CNS-CC, FCCM, Virginia V. Schneider, MPAS, PA-C, Yun Qing, MHS, PhD, Lei Feng, MS, Jeanne Y. Campbell, MPAS, PA-C, Jason W. Myers, ACNP-BC, Marian Von-Maszewski, MD, and Cristina Gutierrez, MD

Cardiopulmonary resuscitation (CPR) can be a life-saving intervention in the right patient population. Up to 209,000 people are treated for in-hospital cardiac arrest (IHCA) each year, with a survival rate to hospital discharge of 24.8% (Benjamin et al., 2019). Although outcomes post IHCA have im...

Review Article

A Study of Advanced Practice Provider Staffing Models and Professional Development Opportunities at National Comprehensive Cancer Network Member Institutions

Annie Austin,(1) Kellyann Jeffries,(2) Diana Krause,(3) Jessica Sugalski,(3) Karen Sharrah,(4) Anne Gross,(5) Danielle Bowers,(5) Daniel Mulkerin,(6) Nancy Brandt,(6) Aaron Begue,(7) Rose Bell,(8) Cheryl Raczyk,(8) Todd Pickard,(9) David Johnson,(10) Vanna Dest,(11) Rory Randall,(12) Gabrielle Zecha,(13) and Kate Kennedy,(1)

There is growing concern that oncologists will soon be in short supply in the US, creating a significant problem for cancer centers across the nation. A 2014 study predicts a shortage of 2,258 medical oncologists and radiation oncologists by 2025. Demand is expected to increase by 40% while clini...

Review Article

Early Detection of Vulvovaginal Graft-Versus-Host Disease: An Integrative Review

Payton L. Ten Hagen, DNP, APRN, FNP-C, Christi Bowe, MSN, APRN, ANP-C, and Joyce E. Dains, DrPH, JD, APRN, FNP-BC, FNAP, FAANP

Hematopoietic stem cell transplantation (HSCT) is a medical procedure used to treat a multitude of conditions, such as malignant, nonmalignant, congenital, and acquired illnesses. Stem cells may be collected from either unrelated (allogeneic) or self (autologous) sources and occurs by way of bone...

Grand Rounds

Addiction in Patients With Cancer: Challenges and Opportunities

Gretchen A. McNally, PhD, ANP-BC, AOCNP®, and Ashley Sica, MSN, RN, CNL

Case Study Jane Doe is a 28-year-old female diagnosed 3 years ago with nodular sclerosis Hodgkin lymphoma. She completed five cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy; however, she did not return to her original treating oncologist for further care (Figur...

Prescriber's Corner

Sacituzumab Govitecan for Treatment of Refractory Triple-Negative Metastatic Breast Cancer

Patrick J. Fleming Jr., PharmD, BCOP, Sylvia Karpio, PharmD candidate, and Nicholas Lombardo, PharmD candidate

There was an estimated 276,480 new cases of breast cancer in the United States in 2020, making breast cancer the most common cancer in women (Siegel et al., 2020). While the rate of new cases has remained stable over the past decade, there has been a steady decline in the death rate. As women rec...

Diagnostic Snapshot

Persistent Fever While on Broad-Spectrum Antibiotics in a Patient With Squamous Cell Carcinoma


History Mr. AK is a 47-year-old male with past medical history of alcoholism, tobacco abuse, and squamous cell carcinoma of the mandible (pT4N0M0, stage IVA, p16–) diagnosed in January 2020. He was status post hemimandibulectomy, tracheostomy, and bilateral selective neck dissection with fibular ...

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