Current Issue

VOL 13 NO 5 • July 2022

This issue’s cover illustration depicts the breakdown of types of Richter transformation. Approximately 90% transform into diffuse large B-cell lymphoma and 10% transform into Hodgkin lymphoma. Artwork by Alexandra Webber © 2022, DNA Illustrations, Inc., Asheville, North Carolina.


Complexities of Care and the Interdisciplinary Team


Many of you who are reading this article are advanced practitioners (APs) and experts in the management of complex patient symptoms. Despite managing “side effects” of treatment for years as a nurse, then an advanced practitioner, I did not fully comprehend the concepts of symptom management, sym...

Research and Scholarship

Improving Cancer Care Delivery: Learnings for Oncology Nurses and Patient Navigation From a National Quality Survey

Jennifer Aversano,(1,2) MSN, RN, OCN®, BMTCN®, Leigh M. Boehmer,(3) PharmD, BCOP, and Alexander Spira,(4,5) MD, PhD, FACP

Cancer of the lung and bronchus remained the leading cause of cancerspecific mortality and was the second leading cause of newly diagnosed cancer cases in the United States in 2019 (Siegel et al., 2019). Non–small cell lung cancer (NSCLC) accounts for the majority (80%–85%) of histological confir...

Research and Scholarship

Solid Pseudopapillary Neoplasm: A Single Institutional Case Series of a Rare Pancreatic Tumor

Kristen Oase,(1) MS, PA-C, Cheryl Meguid,(1) DNP, ACNP, Atsushi Oba,(1,2) Mohammed H. Al-Musawi,(1) MD, MSc, FIBMS-CTV, FRCS (Glasg), Alison Sheridan,(1) MD, Evan Norris,(1) MD, Sanjana Mehrotra,(1) MD, Mark A. Lovell,(3) MD, Richard D. Schulick,(1) MD, MBA, FACS, Steven A. Ahrendt,(1) MD, and Marco Del Chiaro,(1) MD, PhD, FACS

The incidental finding of pancreatic cystic lesions has increased with the use of cross-sectional imaging, with prevalence up to 3% in CT and up to 20% in MRI (Laffan et al., 2008). Pancreatic cystic neoplasms (PCN) are a subtype accounting for approximately 15% of pancreatic cystic lesions (Krom...

Review Article

Measuring Advanced Practice Provider Productivity at the National Comprehensive Cancer Network’s Member Institutions

Diana Krause(1), Karen Sharrah(2), Anne Gross(3), Danielle Bowers(3), Daniel Mulkerin(4), Nancy Brandt(4), Kate Kennedy(5), Annie Austin(5), Aaron Begue(6), Rose Bell(7), Cheryl Raczyk(7), Todd Pickard(8), Timothy Kubal(9), Dave Johnson(9), Kellyann Jeffries(10), Vanna Dest(11), Rory Randall(12), Jessica Sugalski(1), and Gabrielle Zecha(13)

Advanced practice providers (APPs) specializing in oncology are critical team members in cancer centers across the US. Many cancer patients will see an APP team member, which enables oncologists to see more patients, thereby increasing access to care. As the US population ages and fewer medical o...

Review Article

Barriers to Adherence to Cancer Treatments Among Head and Neck Cancer Patients

Jennifer Lynn Miller, PhD, RN, CMSRN, and Julianne Evers, DNP, APRN, AGACNP-BC, CCRN

Head and neck cancer (HNC) includes cancers of the mouth, throat, larynx, nasal cavity, and sinuses. The American Cancer Society (2021a) estimates there were over 54,000 new cases and 10,000 deaths attributed to HNCs in 2021. The most common risk factors for HNC include alcohol and tobacco use, a...

Grand Rounds

Richter Transformation: Clinical Manifestations, Evaluation, and Management

Melanie Douglas, MS, PA-C

Case Study Presentation A 70-year-old Caucasian woman who was diagnosed 2 months ago with chronic lymphocytic leukemia (CLL) via complete blood cell count and peripheral flow cytometry on active surveillance presented to the clinic with a 2-week history of night sweats along with low-grade fevers...

Practice Matters

An Approach to Diagnosis of Richter Transformation in Chronic Lymphocytic Leukemia

Jackie Broadway-Duren, PhD, DNP, APRN, FNP-BC

Chronic lymphocytic leukemia (CLL) is a chronic incurable heterogenous B-cell disease with a highly variable clinical course (Ding, 2018; Rosati et al., 2018; Khan et al., 2018). Richter transformation (RT) is defined as a histologic transformation of CLL to an aggressive lymphoma known as diffus...

Prescriber's Corner

The Current Landscape for METex14 Skipping Mutations in Non–Small Cell Lung Cancer

Alisha Desai,(1) PharmD, and Sandra Cuellar,(2) PharmD, BCOP, FHOPA, FASHP

There are an estimated 609,360 cancer deaths projected to occur in the United States in 2022 (Siegel et al., 2022). Almost one quarter of those cancer deaths are due to lung cancer. These low survival rates reflect 57% of patients diagnosed with metastatic disease for which the 5-year survival ra...

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