Current Issue
VOL 10 NO 7 • SEP/OCT 2019
This issue’s cover illustration depicts the mechanism of action of duvelisib, an oral δ and γ PI3K inhibitor. This dual isoform blockade inhibits the growth and proliferation of malignant B cells and decreases recruitment of support cells within the tumor microenvironment. Blocking the PI3Kδ pathway prevents the growth and survival of malignant B cells, while blocking PI3Kγ affects the recruitment and differentiation of the cells that support the growth and survival of malignant B cells, such as CD4+ T cells and tumor-associated macrophages. Artwork by Alexandra Webber Baker © 2019, DNA Illustrations, Inc., Asheville, North Carolina.EditorialPamela Hallquist Viale, RN, MS, CNS, ANPIt’s almost time for JADPRO Live in Seattle this October. The meeting promises to be another packed 4 days of focused and relevant education for the advanced practitioner (AP). I hope to see you there!
Management of Febrile Neutropenia
Assessment and management of patients experiencing an oncolog...
Quality ImprovementJordan Gabrielsen,(1) PharmD, Gianna Girone,(1) PharmD, Bonita Bennett,(2) BSN, and Anna Jung,(2) PharmD, BCPSLong-acting formulations of somatostatin analogues (SSAs) that are approved for use include octreotide (Sandostatin LAR Depot, Novartis Pharmaceuticals Corporation, 2019a; Sandostatin LAR, Novartis Pharmaceuticals UK Ltd, 2018a), lanreotide (Somatuline Depot, Ipsen Biopharmaceuticals, Inc, 2019; ...
Quality ImprovementStephanie L. Soulia,(1) DNP, RN, ANP-BC, Elizabeth A. Duffy,(2) DNP, RN, CPNP, Kimberly A. Morley,(3) MD, and Ellen M. L. Smith,(2) PhD, APRN, AOCN®, FAANFourteen million cancer survivors are living in the United States today. Due to improved early detection and treatment, this number is expected to double by 2030 (Centers for Disease Control and Prevention, 2016). This increased survival brings its own challenges: Survivors need preparation to tr...
Review ArticleSteven Trifilio, RPh, and Jayesh Mehta, MDInfections that occur during episodes of neutropenic fever (NF) in patients who undergo hematopoietic stem cell transplantation (HSCT) can cause serious morbidity and mortality. Guidelines suggest initiating antibiotic coverage with a broad-spectrum β-lactam antibiotic as the backbone for initial...
Grand RoundsBernadette Labriola, RN, MSN, FNP-CBreast cancer is the second most common cancer diagnosis during pregnancy (Shachar et al., 2017). It occurs in approximately 0.2% to 2.6% of all woman diagnosed with cancer (Shachar et al., 2017). Cervical cancer during pregnancy is the most common cancer diagnosis during pregnancy (Shachar et al...
Practice MattersAmy Hacker-Prietz, PA-C, Eden Stotsky-Himelfarb, BSN, RN, Beth Kozak Onners, RN, MS, CCRN, OCN®, and Janet StreetIn addition to the physical health concerns that a cancer diagnosis brings, a wide spectrum of psychosocial concerns also accompanies a diagnosis. These psychosocial concerns affect not only the patient, but also the family and caregiver, and often to a greater extent. Some oncology patients are ...
Prescriber's CornerLaura Cannon,(1) PharmD, MPH, Emmeline C. Academia,(2) PharmD, and Ashley E. Glode,(2) PharmD, BCOPActivation of the phosphoinositide 3-kinase (PI3K) pathway has become an area of interest in cancer pathophysiology and drug development. The PI3K pathway plays a primary role in cell signaling and cellular responses such as proliferation and metabolism, and overexpression of PI3K isoforms may be...
Prescriber's CornerKori Daniels, PharmD, and Amber Clemmons, PharmD, BCOPCytomegalovirus (CMV) is a ubiquitous double-stranded DNA herpes virus that infects over 50% of adults by age 40 (Bhat, Joshi, Sarode, & Chavan, 2015). Transmission most commonly occurs through direct contact with bodily fluids (e.g., saliva or urine), sexual contact, perinatally (in utero, t...
Diagnostic SnapshotElizabeth Wolf, PA-CHISTORY
VD is a 44-year-old female who presented on July 10, 2018, to the Urology clinic with a left renal pelvis lesion. She initially had an episode of abdominal pain on March 29, 2018, that prompted a CT scan of the abdomen and pelvis. The CT showed an abnormality in the left upper pole with c...
